Immune biomarkers for predicting response to adoptive cell transfer as cancer treatment

Adoptive cell transfer as personalized immunotherapy for human cancer.

Adoptive cell therapy (ACT) is a highly personalized cancer therapy that involves administration to the cancer-bearing host of immune cells with direct anticancer activity. ACT using naturally occurring tumor-reactive lymphocytes has mediated durable, complete regressions in patients with melanoma, probably by targeting somatic mutations exclusive to each cancer. These results have expanded the...

Allogeneic adoptive cell transfer therapy as a potent universal treatment for cancer

Adoptive cell transfer (ACT), the transfer of therapeutic lymphocytes to patients, is a promising cancer treatment, with advances seen in patients with melanoma and neuroblastoma in early clinical trials [1, 2]. One type of ACT modality pioneered by our group relies on the use chimeric antigen receptors (CAR) redirected T cells [3, 4]. CARs are typically composed of single chain antibody fragme...

Active Immunotherapy and Adoptive Cell Transfer as an Effective Cancer Treatment

Prospects in Adoptive Cell Transfer Therapy for Cancer

It has been documented that immunosurveillance plays an important role in cancer development in both human and animals [1,2]. Cancer immunosurveillance is the function of immune system in recognizing and reacting against aberrant cancer cells in the body. Thus, the interactions between cancer cells and immune cells play a pivotal role in cancer development. In cancer patients, however, tumors g...

A review on miRNAs as new biomarkers for colorectal cancer

Background & Objective: Since colorectal cancer does not often have phenotypic symptoms in the early stages, the study of biomarkers for the diagnosis and prognosis of the tumor is very important. MicroRNAs are one of the most important biomarkers which attract the attention of many researchers due to a variety of reasons, including their non-invasive nature; these molecules are a group of non-...